Select Journal or Resource JAMA & Archives Home JAMA Archives of   Dermatology   Facial Plastic Surgery   Family Medicine (1992-2000)   General Psychiatry   Internal Medicine   Neurology   Neurology and Psychiatry (1919-1959)   Ophthalmology   Otolaryngology—Head & Neck Surgery   Pediatrics & Adolescent Medicine   Surgery JAMA-français JAMA & Archives CME Calendar of Events JAMA Career Center For The Media JAMAevidence Peer Review Congress Student JAMA (1998-2004)

	Institution: CLOCKSS  | My Account | E-mail Alerts | Access Rights | Sign In Vol. 8 No. 3, May 1999   Archives  •  Online Features Clinical Review  This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (17)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Men's Health  • Men's Health, Other  • Alert me on articles by topic Current Status of Testosterone Replacement Therapy in Men Stephen J. Winters, MD Arch Fam Med. 1999;8:257-263. Testosterone plays an essential role in the development of the normal male and in the maintenance of many male characteristics, including muscle mass and strength, bone mass, libido, potency, and spermatogenesis. Androgen deficiency occurs with disorders that damage the testes, including traumatic or surgical castration (primary testicular failure) or disorders in which the gonadotropin stimulation of the testes is reduced (hypogonadotropic hypogonadism). The clinical manifestations of androgen deficiency depend on the age at onset and the severity and duration of the deficiency. In adult males, these manifestations may include reduced body hair, decreased muscle mass and strength, increased fat mass, decreased hematocrit, decreased libido, erectile dysfunction, infertility, osteoporosis, and depressed mood. The forms of androgen replacement currently available in the United States are intramuscular depot injections of testosterone esters, oral tablets of testosterone derivatives, and transdermal patches. For most patients, androgen replacement therapy with testosterone is a safe, effective treatment for testosterone deficiency. From the Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pa. RELATED ARTICLE The Archives of Family Medicine Continuing Medical Education Program Arch Fam Med. 1999;8(3):207-209. FULL TEXT   THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES Impact of IGF-I and CYP19 Gene Polymorphisms on the Survival of Patients With Metastatic Prostate Cancer Tsuchiya et al. JCO 2006;24:1982-1989. ABSTRACT | FULL TEXT   Population variation in age-related decline in male salivary testosterone Ellison et al. Hum Reprod 2002;17:3251-3253. ABSTRACT | FULL TEXT   Andropause: Knowledge and Perceptions Among the General Public and Health Care Professionals Anderson et al. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2002;57:M793-796. ABSTRACT | FULL TEXT   Testosterone in Aging Men Applegate and Winters Arch Fam Med 2000;9:221-221. FULL TEXT   Testosterone reduces neuronal secretion of Alzheimer's beta -amyloid peptides Gouras et al. Proc. Natl. Acad. Sci. USA 2000;97:1202-1205. ABSTRACT | FULL TEXT   HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | HELP CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP   © 1999 American Medical Association. All Rights Reserved.