Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1533-4368
Volume
3
Year
2006

Article Facts

Title
BMP and its antagonists
DOI
10.1138/20060205
Authors

Masaki Noda

Online Date
04/00/2006

Article Links

BoneKEy-Osteovision | Perspective

BMP and its antagonists

Masaki Noda


DOI:10.1138/20060205

Abstract

Bone morphogenetic protein (BMP) is necessary for the development of mesenchymal tissue and mesoderm formation during development. BMP2 and BMP4 play critical roles in morphogenesis. On the other hand, BMP5, BMP6 and BMP7, which were discovered more recently, likely serve as specific modulators of the development of other tissues. There are several inhibitory molecules that seem able to target BMP functioning, including SOST, Tob, CIZ and Noggin. These molecules appear to help determine the levels of bone mass in adult mice. Further analysis is necessary to elucidate the specific functions of BMP inhibitors and BMPs in adult bone.

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