MDMA (Ecstasy)

Rif S. El-Mallakh MD
Henry David Abraham MD

pages: 45 - 52

• DOI: 10.1080/10401230601163592
• Version of record first published: 12Feb2007

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Abstract:

Background. 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) is a synthetic amphetamine analogue that is recreationally used to obtain a psychological effect of enhanced affiliative emotional response. Its use in Western countries appears to be increasing, particularly among young individuals.

Methods. Pertinent basic and clinical literature is critically reviewed.

Results. A significant body of literature suggests that the patterns of MDMA use differ from traditional drugs of abuse, with relatively uncommon dependence and escalation of dosage. Nonetheless, MDMA is also neurotoxic with significant deleterious effects on serotonergic neurons, memory, and mood. Despite this, there is a dearth of treatment strategies for both acute intoxication and consequences of longer term use.

Conclusions. MDMA is an important drug of abuse that has a wide range of adverse consequences.