Chronology and Summary of Abel’s Research Contributions
Year | Topic | Contribution to pharmacology |
---|---|---|
1894 | ethyl sulfide, calcium carbamate | isolation of simple organic substances from natural sources |
1895 | thyroid gland | extraction and isolation of active substances |
1895 – 1905 | epinephrine | isolation of a physiologically active monobenzoyl derivative from adrenal gland |
1896 | melanins | chemical composition |
1907 | frog muscle | physiological action of ions across muscle membrane |
1907 – 1908 | hemolysin, Amanita phalloides | isolation of mushroom poisons and production of antisera |
1909 | phthaleins | purgative action, absorption, and excretion of phthalein derivatives |
1909 – 1911 | organic arsenicals, antimony | chemotherapeutic action and treatment of experimental trypanosomiasis |
1910 | acid fuchsin | mechanism of action of tetanic convulsions |
1912 | parotid gland, Bufo aqua | isolation of epinephrine |
1912 – 1913 | artificial kidney | first demonstration of amino acids in the blood; isolated 3 amino acids |
1914 | plasmapheresis | removal of plasma and retransfusion of packed red blood cells into the donor |
1917 | albumoses (protein fractions) | isolation of physiologically active substances (proteins) from tissues and blood |
1917 – 1931 | posterior pituitary hormones | investigation of an active, single substance in posterior pituitary |
1924 | Witte’s peptone | separation and pharmacological actions of active substances |
1924 – 1927 | insulin | purification and first crystallization of insulin |
1932 – 1938 | tetanus toxin | demonstrated dual action of tetanus toxin and distribution by the vascular and lymphatic systems |