Non-Synonymous Mutations in VKORC1 Leading to Warfarin Resistance
Amino acid change | Daily Dose | Resistance Phenotype | Reference |
---|---|---|---|
Val29 → Leu | 14 mg | Moderate | (8) |
Ala41 → Ser | 16 mg | (9) | |
Arg58 → Gly | 32–36 mg | Major | (8) |
Val66 → Met | 27–35 mg | (29) | |
Leu128 → Arg | > 45 mg | Severe | (8, 30) |
Val45 → Ala | Target INR never reached | (8) |