Classification of PDZ Domains Based on the C-terminal Sequence of Their Binding Partners
Class | C-terminal Sequence | Interacting Proteins | Example of PDZ Domain |
---|---|---|---|
Φ: Hydrophobic. X: Unspecified | |||
Class I -X-S/T-X- Φ | ETDV | Shaker K+ channel | PSD-95 (PDZ2) |
ESDV | NMDAR2A/B | PSD-95 (PDZ2) | |
TTRV | Neuroligin | PSD-95 (PDZ3) | |
QSAV | Voltage-gated Na + channel | Syntrophin | |
DSSL | Protein Kinase Cα | PICK1 | |
DTRL | β2-adrenergic receptor | NHERF (PDZ1) | |
SSTL | GKAP or mGluR5 | Shank | |
Class II -X Φ-X- Φ | SVKI | GluR2 | PICK1, GRIP(PDZ5) |
EYYV | Neurexin | CASK | |
EFYA | Syndecan-2 | CASK, Syntenin (PDZ2) | |
YYKV | Ephrin B1 | PICK1, GRIP(PDZ6) | |
DVPV | ErbB2 | Erbin | |
Class III -X-D/E-X- Φ | VDSV | Melatonin receptor | nNOS |
GEPL | KIF17 | mLIN10,Mint1,X11 | |
FEEL | Merlin | Syntenin |