Cytochrome P450 Gene Deletions
P450 | Constitutive Phenotype | Genetic Background | Comments | Citation |
---|---|---|---|---|
CYP1A1 | None | 129xC57BL/6 | Protection against BaP toxicity | (4) |
CYP1A2 | Respiratory distress | 129xC57BL/6 | Disruption of exon 2 Incomplete penetrance | (6, 10) |
None | 129xCF-1 | Disruption of exon 2, removal of exons 3–5 | ||
Deficient zoxazolamine metabolism | ||||
CYP1B1 | None | 129xC57BL/6 | Protection against DMBA-induced bone marrow cytotoxicity and ovarian cancer | (11) |
CYP2E1 | None | 129xC57BL/6 | Resistant to acetaminophen, chloroform and carbon tetrachloride hepatotoxicity | (12) |
CPR (liver-specific)[HRN™] | Altered hepatic lipid homeostasis | 129xC57BL/6 C57BL/6 | No hepatic P450 function, altered drug pharmacokinetics, reduced acetaminophen toxicity | (23, 26) |
CYP7A1 | Lethal in postnatal period (<18d) | 129xC57BL/6 | Rescued by dietary supplementation Alternative bile acid biosynthetic pathway induced | (14, 15) |
CYP19 | Females infertile Precocious follicular depletion | 129xC57BL/6 | Disruption of exon 9 Partial rescue with estradiol treatment | (17) |
Females infertile Corpora lutea absent | 129xC57BL/6 | Disruption of exon 9 Enlargement of prostate gland Increased adiposity | (16) | |
CYP26A1 | Embryonic lethal, mid-late gestation | 129xC57BL/6 | Deletion of exons 2–6 Spina bifida, sirenomelia, caudal truncation | (18) |
Lethal in perinatal period (<24h) | 129xC57BL/6 | Deletion of entire gene Caudal truncation, vertebra transformation, hindbrain mispatterning | (19) |