S-nitrosylation of Transription Factors
Transcription Factor | Cell Type | Site | Effect | Concentration of NO donor | References |
---|---|---|---|---|---|
NF-κB | A549 | Cys62 on p50 | Alters p50–p65 dimer formation | 0.5–1 mM CSNO + TNFα | Marshall and Stamler (50) |
Jurkat | Inhibit IκBα formation | 0.5 mM CSNO 0.5 mM DETA-NONOate + TNF | Marshall and Stamler (73) | ||
HSC-1 HeLa | (1) Blocks degradation of IB (2) Increases DNA binding activity | Thioredoxin | Hirota et al. (74) | ||
Human saphenous vein endothelial cells | Induction and stabilization of IκBα | 0.2-0.5 mM GSNO or 0.5 mM SNP + TNF | Peng et al. (75) | ||
OxyR | E. coli | Cys199 | Response to nitrosative stress | 0.2 mM SNO-Cys | Kim et al. (52) |
HIF-1α | BPAEC | Stabilization of α subunit | 0.1 mM GSNO, 0.5 mM NOC-18 | Palmer et al. (42) | |
Sp1–Sp3 | A549 | Switch in DNA Binding Activity from Sp1 (high conc.) to Sp3 (low conc.) | 0.01-0.5 mM GSNO | Zaman et al. (48) |