Table of Contents

Reviews

• Select this article
  • Yuan Zhang and
  • David J. Mangelsdorf

  LuXuRies of Lipid Homeostasis: The Unity of Nuclear Hormone Receptors, Transcription Regulation, and Cholesterol Sensing

  Mol Interv April 2002 2:78-87; doi:10.1124/mi.2.2.78
  • Abstract
  • Full Text
  • Full Text (PDF)

  The nuclear transcription factors LXRα and LXRβ help to control circulating levels of fatty acids and cholesterol by stimulating the expression of genes associated with lipid and sterol modification, storage, and removal. Knowing how the expression and the activity of these transcription factors are regulated may aid in the development of treatments for disorders of lipid storage and elimination.

• Select this article
  • Randall J. Kimple,
  • Francis S. Willard,
  • and David P. Siderovski

  The GoLoco Motif: Heralding a New Tango Between G Protein Signaling and Cell Division

  Mol Interv April 2002 2:88-100; doi:10.1124/mi.2.2.88
  • Abstract
  • Full Text
  • Full Text (PDF)

  Although the Gα and the Gβγ subunits of heterotrimeric G proteins can effect different signaling processes in cells, the mechanisms that govern their different signaling outcomes have been underappreciated. GoLoco motif-containing proteins bind specifically to Gα loaded with GDP, and hinder Gβγ from re-associating to Gα. Thus, Gβγ-dependent signals may be sustained. Additionally, “GoLoco proteins” may have effector functions themselves, particularly in the regulation of cell division.

• Select this article
  • Stefanie S. Jeffrey,
  • Michael J. Fero,
  • Anne-Lise Børresen-Dale,
  • and David Botstein

  Expression Array Technology in the Diagnosis and Treatment of Breast Cancer

  Mol Interv April 2002 2:101-109; doi:10.1124/mi.2.2.101
  • Abstract
  • Full Text
  • Full Text (PDF)

  Just a few years ago, the amazing thing about microarrays was that they worked; today, microarrays astound with the detail of biomedical information they can provide. Breast cancer research is a prime example, where microarrays are helping to establish etiology, diagnosis, and treatment strategies.