Nomenclature and Subcellular Localization for AKAPs, Splice Variants, Isoforms, Orthologs, and Associating Molecules
AKAP | Associating Molecules | Targeting Motifs/Localization | References | |
---|---|---|---|---|
AKAP-Lbc | PKD | α-Catulin | Actin cytoskeleton cytoplasm | (51–55, 57–60, 87, 88) |
Brx | PKCη | |||
proto-Lbc | Rho | |||
Onco-Lbc | 14-3-3 | |||
AKAP13 | LC3 | |||
AKAP18 (α, β, γ, δ) | CaV1.1/1.2 | AQP2 | Plasma membrane (α and β myristoylation, dual palmitoylation) | (89–97) |
AKAP15 | PLB | NaV1.2a | ||
AKAP7 | PDE4D | 5’-AMP | Cytosolic and nuclear (γ and δ NLS) | |
AKAP79 | PKC | β1-AR | Plasma membrane (Polybasic domain interaction with PIP2) | (15, 17, 61–64, 74, 76, 83, 88–108) |
AKAP150 | GluR1 | SAP97 | ||
AKAP75 | mGluR1/5 | PSD-95 | Postsynaptic densities (SAP97) | |
AKAP5 | AC5/6 | PP2B | ||
KCNQ2 | CaV1.2 | |||
Kir2.1 | ASIC1a/2a | |||
TRPV1 | NMDAR | |||
IQGAP1 | ||||
mAKAP | PDE4D3 | RyR | Nuclear envelope (Nesprin-1α) | (80, 109–117) |
AKAP100 | Nesprin-1α | NCX | Sarcoplasmic reticulum (RyR) | |
AKAP6 | Epac | MEK/ERK5 | ||
PDK1 | AC5 | |||
Siah2 | HIF-1α | |||
VHL | ||||
Gravin (α,β,γ) | PKC | Myristoylated | (118–124) | |
AKAP250 | β2-AR | Membrane | ||
AKAP12 | CyclinD | Cytoskeleton | ||
D-AKAP1 | PP1 | RSK1 | Mitochondria | (14, 125–136) |
AKAP84 | PTPD1 | PP2Ac | Endoplasmic reticulum | |
S-AKAP84 | Lamin B | |||
AKAP121 | PDE7A | |||
AKAP140 | AMY-1 | |||
AKAP149 | HIV-1 RT | |||
AKAP1 | mRNA | |||
CG-NAP | PP1 | PKN | Centrosome (PACT domain) | (19–21, 137) |
Yotiao | NMDAR | GCP2/3 | Golgi | |
Hyperion | KCNQ1 | CLIC | Plasma membrane | |
AKAP350 | IP3R | PP2A | ||
AKAP450 | PKCɛ | |||
AKAP120 | CK1 | |||
AKAP9 | PDE4D3 | |||
Rab32 | Varp | CD44 | Myofilaments | (138–141) |
ICAM-1/2 | ||||
RhoGDI | ||||
S100P | ||||
WWOX | ||||
Myospryn | Desmin | Dystrophin | N-Terminal prenylation | (142–144) |
Dysbindin | ||||
Pericentrin | PKC | Tubulin | Centrosome (PACT domain) | (34, 145–147) |
MAP2 | Tubulin | Myosin VIIa | Microtubules | (98, 148–153) |
A,B,C,D | F-actin | Fyn | ||
Src | CaV1.2 | |||
Grb2 | ||||
AKAP220 | PP1 | GABACR | Vesicles | (154–159) |
AKAP11 | GSK3β | AQP2 | ||
Ezrin | CFTR | Actin cytoskeleton | (160–166) | |
AKAP78 | EBP50 | |||
EZR | NHERF | |||
FAK | ||||
Merlin | ||||
AKAP95 | Condensin | p68 RNA | Nuclear matrix | (129, 132, 166–170) |
AKAP8 | PDE7A | helicase | ||
AMY-1 | MCM2 |