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Graft, Vol. 6, No. 1, 18-20 (2003)
DOI: 10.1177/1522162802239753
© 2003 SAGE Publications

Spreading of T Cell Responses to Autoantigens after Allotransplantation and Its Potential Involvement in the Rejection Process

Gilles Benichou, PhD, DSc

Harvard Medical School

Key Words: allotransplantation • autoimmunity • T cells • T cell tolerance • inflammation

References

  • 1. Kappler JW, Staerz U, White J, Marrack PC. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex . Nature 1988;332: 35-40 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 2. Benichou G, Tam RC, Orr PI, Garovoy MR, Fedoseyeva EV. Self determinant selection and acquisition of the autoimmune T cell repertoire . Immunol Res 1996;15: 234-45 .[Medline] [Order article via Infotrieve]OpenURL
  • 3. Lehmann PV, Sercarz EE, Forsthuber T, Dayan CM, Gammon G. Determinant spreading and the dynamics of the autoimmune T-cell repertoire . Immunol Today 1993;14: 203-8 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 4. Lehmann PV, Forsthuber T, Miller A, Sercarz EE. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen . Nature 1992;358: 155-7 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 5. Lehmann PV, Targoni OS, Forsthuber TG. Shifting T-cell activation thresholds in autoimmunity and determinant spreading . Immunol Rev 1998;164: 53-61 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 6. Fedoseyeva EV, Tam RC, Popov IA, Orr PL, Garovoy MR, Benichou G. Induction of T cell responses to a self-antigen following allotransplantation . Transplantation 1996;61: 679-83 .[CrossRef][Medline] [Order article via Infotrieve]OpenURL
  • 7. Fedoseyeva EV, Zhang F, Orr PL, Levin D, Buncke HJ, Benichou G. De novo autoimmunity to cardiac myosin after heart transplantation and its contribution to the rejection process . J Immunol 1999;162: 6836-42 .[Abstract/Free Full Text]
  • 8. Fedoseyeva EV, Kishimoto K, Rolls HK, Illigens BM, Dong VM, Valujskikh A, et al. Modulation of tissue-specific immune response to cardiac myosin can prolong survival of allogeneic heart transplants . J Immunol 2002;169: 1168-74 .[Abstract/Free Full Text]
  • 9. Jurcevic S, Ainsworth ME, Pomerance A, Smith JD, Robinson DR, Dunn MJ, et al. Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation . Transplantation 2001;71: 886-92 .[Medline] [Order article via Infotrieve]OpenURL
  • 10. Mares DC, Heidler KM, Smith GN, Cummings OW, Harris ER, Foresman B, et al. Type V collagen modulates alloantigen-induced pathology and immunology in the lung . Am J Respir Cell Mol Biol 2000;23: 62-70 .[Abstract/Free Full Text]
  • 11. Valujskikh A, Fedoseyeva EV, Benichou G, Heeger PS. Development of autoimmunity following skin graft rejection via an indirect alloresponse . Transplantation 2002;73: 1130-7 .[Medline] [Order article via Infotrieve]OpenURL
  • 12. Yasufuku K, Heidler KM, O’Donnell PW, Smith GN, Jr, Cummings OW, Foresman BH, et al. Oral tolerance induction by type V collagen downregulates lung allograft rejection . Am J Respir Cell Mol Biol 2001;25: 26-34 .[Abstract/Free Full Text]
  • 13. Benichou G, Fedoseyeva EV. Induction of T cell responses to tissue-specific antigens: immune mechanisms and role in transplant rejection . Graft 2002;5: 352-9 .[Abstract]

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This Article
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