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Graft, Vol. 5, No. 1, 27-33 (2002)
© 2002 SAGE Publications

Transplantation Tolerance: Of Mice and Men

Dengping Yin

Rush-Presbyterian-St. Luke's Medical Center

Ian A. Boussy

Rush-Presbyterian-St. Luke's Medical Center

Anita S. Chong

Rush-Presbyterian-St. Luke's Medical Center

Most strategies that successfully induce transplantation tolerance in murine models have failed upon translation into clinical therapies, and transplantation tolerance remains an elusive clinical goal. The disparity in outcome between mouse and human studies has led some investigators to cynically question whether data on tolerance in mice have any relevance to humans. The authors believe that this cynicism is overly negative and that principles of immune tolerance in humans can be revealed with mouse models. In this review, the authors discuss why the lessons of transplantation tolerance learned from mice have not directly translated into large animals, and how to overcome this problem.

Key Words: tolerance • organ transplantation • rodents • bone • costimulation


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