Journal Facts

Journal
BoneKEy Knowledge Environment
ISSN
1533-4368
Volume
4
Year
2007

Article Facts

Title
As a matter of fat: New perspectives on the understanding of age-related bone loss
DOI
10.1138/20070257
Authors

Gustavo Duque

Online Date
04/00/2007

Article Links

BoneKEy-Osteovision | Perspective

As a matter of fat: New perspectives on the understanding of age-related bone loss

Gustavo Duque


DOI:10.1138/20070257

Abstract

Aging is associated with increasing levels of bone marrow fat. This fat is the consequence of the predominant differentiation of mesenchymal stem cells into the adipocyte lineage at the expense of osteoblastogenesis. Furthermore, the reduction in osteoblastogenesis as well as the short life span seen in osteoblasts during aging in bone is the predominant pathophysiological mechanism of senile osteoporosis. In this review, the mechanisms of bone marrow fat infiltration and the potential toxic effects of fat accumulation in bone marrow will be considered. In addition, the potential therapeutic use of bone marrow fat for the prevention and treatment of senile osteoporosis is also proposed.

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