BoneKEy-Osteovision | Perspective

As a matter of fat: New perspectives on the understanding of age-related bone loss

Gustavo Duque



Aging is associated with increasing levels of bone marrow fat. This fat is the consequence of the predominant differentiation of mesenchymal stem cells into the adipocyte lineage at the expense of osteoblastogenesis. Furthermore, the reduction in osteoblastogenesis as well as the short life span seen in osteoblasts during aging in bone is the predominant pathophysiological mechanism of senile osteoporosis. In this review, the mechanisms of bone marrow fat infiltration and the potential toxic effects of fat accumulation in bone marrow will be considered. In addition, the potential therapeutic use of bone marrow fat for the prevention and treatment of senile osteoporosis is also proposed.

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