Indian Journal of Human Genetics
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ORIGINAL ARTICLE
Year : 2013  |  Volume : 19  |  Issue : 3  |  Page : 342-345

Population based family history analysis of Brahmins in a small town in India for the prevalence of type-2 diabetes mellitus


1 Department of Zoology, A.S.C. College, Rahuri, District Ahemadnagar, Maharashtra, India
2 Sanjeevani Hospital, Rahuri, District Ahemadnagar, Maharashtra, India
3 Consultant, Cipla Palliative Care and Training Centre, Pune, Maharashtra, India

Correspondence Address:
Arun V Panat
Department of Zoology, A.S.C. College, Rahuri - 413 705, Ahemadnagar, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.120826

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Objectives: The objective of this study is to determine the inheritance pattern of type-2 diabetes and make stratification for the general population risk. Materials and Methods: A questionnaire was developed for o btaining the family history. Analysis of the data was carried out by using student and Chi-square tests and for stratification; the guidelines of Scheuner et al. were followed. Results: The pattern of inheritance is the male sex specific (χ² =13.44). The mean age of onset of diabetes in parents was 58.61 ± 2.94 and in offspring 46.75 ± 2.54. In all 47.22 ± 11.53% families were found in high risk and 31.94 ± 10.77% in the moderate risk category. In female diabetics, the onset was in the age range of 41-60 years. Conclusion: We found a high-risk of diabetes and familial clustering in successive generations of Brahmins with prominent male sex specificity. In females onset of diabetes was coinciding with the period around menopause.


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