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LETTER TO THE EDITOR
Year : 2013  |  Volume : 19  |  Issue : 2  |  Page : 273-274
 

Large scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals


Laboratory of Human Genetics and Molecular Pathology, Faculty of Medicine, UH2C, Casablanca, Morocco

Date of Web Publication5-Aug-2013

Correspondence Address:
Khalil Hamzi
Laboratory of Human Genetics and Molecular Pathology, Faculty of Medicine, UH2C, Casablanca
Morocco
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.116112

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How to cite this article:
Hamzi K, Diakité B, Tazzite A, Nadifi S. Large scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals. Indian J Hum Genet 2013;19:273-4

How to cite this URL:
Hamzi K, Diakité B, Tazzite A, Nadifi S. Large scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals. Indian J Hum Genet [serial online] 2013 [cited 2016 May 24];19:273-4. Available from: http://www.ijhg.com/text.asp?2013/19/2/273/116112


Sir,

Kumar et al. [1] commented our systematic review [2] on a large scale meta-analysis of genetic studies in ischemic stroke.

Casas et al. [3],[4] made 2 different studies with different sample size (3,387 cases, 4,597 controls and 6,324 cases, 7,604 controls), the 2 works are reported in Bersano et al. [5] which had normally increased the sample size.

We followed the same criteria for selection of studies for the five genes polymorphisms (Prothrombin, Factor V Leiden, Angiotensin Converting Enzyme, Methylenetetrahydrofolate Reductase and Apolipoproteine E gene meta-analysis since we selected works with the pooling of 5 genes in same ethnic population with strict criteria.

 
   References Top

1.Kumar A, Kumar P, Sahu JK. Large scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,297 individuals. Indian J Hum Genet 2012;18:270.  Back to cited text no. 1
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2.Hamzi K, Tazzite A, Nadifi S. Large-scale meta-analysis of genetic studies in ischemic stroke: Five genes involving 152,797 individuals. Indian J Hum Genet 2011;17:212-7.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.Casas JP, Hingorani AD, Bautista LE, Sharma P. Meta-analysis of genetic studies in ischemic stroke: Thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol 2004;61:1652-61.  Back to cited text no. 3
    
4.Casas JP, Bautista LE, Smeeth L, Sharma P, Hingorani AD. Homocysteine and stroke: Evidence on a causal link from mendelian randomisation. Lancet 2005;365:224-32.  Back to cited text no. 4
    
5.Bersano A, Ballabio E, Bresolin N, Candelise L. Genetic polymorphisms for the study of multifactorial stroke. Hum Mutat 2008:29(6):776-95.  Back to cited text no. 5
    




 

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