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LETTER TO THE EDITOR
Year : 2013  |  Volume : 19  |  Issue : 2  |  Page : 273
 

Micro-RNAs in IVF outcome


1 Department of Biology, Bonab Branch, Islamic Azad University, Bonab, Iran
2 Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Date of Web Publication5-Aug-2013

Correspondence Address:
Saeid Ghorbian
Department of Biology, Bonab Branch, Islamic Azad University, Bonab
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.116110

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How to cite this article:
Ghorbian S, Zonouzi AP. Micro-RNAs in IVF outcome. Indian J Hum Genet 2013;19:273

How to cite this URL:
Ghorbian S, Zonouzi AP. Micro-RNAs in IVF outcome. Indian J Hum Genet [serial online] 2013 [cited 2016 May 24];19:273. Available from: http://www.ijhg.com/text.asp?2013/19/2/273/116110


Sir,

The advancement on assisted reproductive technologies increased hope to childbearing in couples of infertile. In vitro fertilization (IVF) is one of these technologies. Of note, currently the best success rate of IVF is approximately 30% for female age 35. [1] The blastocyst establishment inside maternal uterus is very important in reproduction procedure at the early stage of pregnancy. Furthermore, there are many factors may be affected to reception of embryo in endometrium of uterus. [2],[3] Although some of the factors is still unknown. However, several of investigations revealed that miRNAs have potential regulatory in endometrial receptivity. [4],[5],[6] MiRNAs are small non-coding RNA molecules that regulate mRNA translation initiation and degradation. [7] In one of recent study, Revel et al. were able to identify a number of miRNAs that were dysregulated in the repeated implantation failure (RIF). The RIF is a major problem encountered in IVF. [8] Furthermore, with assessment the crucial regulatory roles of miRNA in gene expression in receptivity, we are able to increased success rates of IVF outcome as an optimistically. However, miRNAs could be introduced as novel molecular markers for assessment human blastocyst receptivity in RIF patients.

 
   References Top

1.ESHRE Capri Workshop Group. Failures (with some successes) of assisted reproduction and gamete donation programs. Hum Reprod Update 2013.  Back to cited text no. 1
    
2.Wang H, Dey SK. Roadmap to embryo implantation: Clues from mouse models. Nat Rev Genet 2006;7:185-99.  Back to cited text no. 2
    
3.Hu SJ, Ren G, Liu JL, Zhao ZA, Yu YS, Su RW, et al. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem 2008;283:23473-84.  Back to cited text no. 3
    
4.Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update 2010;16:142-65.  Back to cited text no. 4
    
5.Altmae S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, et al. MicroRNAs miR-30b, miR-30d, and miR-494 Regulate Human Endometrial Receptivity. Reprod Sci 2012;20:308-17.  Back to cited text no. 5
    
6.Altmae S, Martinez-Conejero JA, Salumets A, Simon C, Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010;16:178-87.  Back to cited text no. 6
    
7.Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009;136:21533.  Back to cited text no. 7
    
8.Revel A, Achache H, Stevens J, Smith Y, Reich R. MicroRNAs are associated with human embryo implantation defects. Hum Reprod. 2011;26:2830-40.  Back to cited text no. 8
    




 

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