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LETTER TO THE EDITOR |
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Year : 2013 | Volume
: 19
| Issue : 2 | Page : 273 |
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Micro-RNAs in IVF outcome
Saeid Ghorbian1, Ahmad Poursadegh Zonouzi2
1 Department of Biology, Bonab Branch, Islamic Azad University, Bonab, Iran 2 Department of Cellular and Molecular Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran
Date of Web Publication | 5-Aug-2013 |
Correspondence Address: Saeid Ghorbian Department of Biology, Bonab Branch, Islamic Azad University, Bonab Iran
Source of Support: None, Conflict of Interest: None
DOI: 10.4103/0971-6866.116110
How to cite this article: Ghorbian S, Zonouzi AP. Micro-RNAs in IVF outcome. Indian J Hum Genet 2013;19:273 |
Sir,
The advancement on assisted reproductive technologies increased hope to childbearing in couples of infertile. In vitro fertilization (IVF) is one of these technologies. Of note, currently the best success rate of IVF is approximately 30% for female age 35. [1] The blastocyst establishment inside maternal uterus is very important in reproduction procedure at the early stage of pregnancy. Furthermore, there are many factors may be affected to reception of embryo in endometrium of uterus. [2],[3] Although some of the factors is still unknown. However, several of investigations revealed that miRNAs have potential regulatory in endometrial receptivity. [4],[5],[6] MiRNAs are small non-coding RNA molecules that regulate mRNA translation initiation and degradation. [7] In one of recent study, Revel et al. were able to identify a number of miRNAs that were dysregulated in the repeated implantation failure (RIF). The RIF is a major problem encountered in IVF. [8] Furthermore, with assessment the crucial regulatory roles of miRNA in gene expression in receptivity, we are able to increased success rates of IVF outcome as an optimistically. However, miRNAs could be introduced as novel molecular markers for assessment human blastocyst receptivity in RIF patients.
References | | |
1. | ESHRE Capri Workshop Group. Failures (with some successes) of assisted reproduction and gamete donation programs. Hum Reprod Update 2013. |
2. | Wang H, Dey SK. Roadmap to embryo implantation: Clues from mouse models. Nat Rev Genet 2006;7:185-99. |
3. | Hu SJ, Ren G, Liu JL, Zhao ZA, Yu YS, Su RW, et al. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem 2008;283:23473-84. |
4. | Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update 2010;16:142-65. |
5. | Altmae S, Martinez-Conejero JA, Esteban FJ, Ruiz-Alonso M, Stavreus-Evers A, Horcajadas JA, et al. MicroRNAs miR-30b, miR-30d, and miR-494 Regulate Human Endometrial Receptivity. Reprod Sci 2012;20:308-17. |
6. | Altmae S, Martinez-Conejero JA, Salumets A, Simon C, Horcajadas JA, Stavreus-Evers A. Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility. Mol Hum Reprod 2010;16:178-87. |
7. | Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009;136:21533. |
8. | Revel A, Achache H, Stevens J, Smith Y, Reich R. MicroRNAs are associated with human embryo implantation defects. Hum Reprod. 2011;26:2830-40. |
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