Indian Journal of Human Genetics
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CASE REPORT
Year : 2012  |  Volume : 18  |  Issue : 3  |  Page : 349-351

An uncommon case of an adult with del(5)(q) in acute lymphoblastic leukemia


1 Department of Molecular Biology, Triesta Reference Laboratory, HealthCare Global Enterprises Ltd, Bangalore, India
2 Department of Medical Oncology, HealthCare Global Enterprises Ltd, Bangalore, India
3 Department of Cytogenetics, Kidwai Memorial Institute of Oncology (KMIO), Dharmaram College Post, Hosur Road, Bangalore, India

Correspondence Address:
Prasannakumari
Triesta Sciences, Health Care Global Enterprises (HCG), Tower - 1, #8, P. Kalinga Rao Road, Sampangi Ram Nagar, Bangalore - 560 027
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.108028

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Del(5)(q) is a common chromosomal abnormality with favourable prognosis in Myelodysplastic Syndrome (MDS) and Acute myeloid leukemia (AML). However, del(5)(q) is also seen rarely in Acute lymphoblastic leukemia (ALL) and its significance remains poorly understood. We present here, a case report of diagnosis of an adult 75 year old patient of ALL with a cytogenetic abnormality of del(5)(q32). His clinical features, morphology and immunophenotyping findings were suggestive of T-ALL. Relevant literature has been reviewed and discussed.


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