Indian Journal of Human Genetics
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Year : 2011  |  Volume : 17  |  Issue : 3  |  Page : 126-131

Neural tube defects between folate metabolism and genetics


Department of Biological Sciences, Yarmouk University, Irbid, Jordan,

Correspondence Address:
Helmi Y Alfarra
508 -1094 Wellington Street, Halifax, Nova Scotia, Canada, B3H 2Z9

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0971-6866.92082

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Neural tube defects (NTDs) are the second most common severely disabling human congenital defects. Worldwide, NTDs incidence is approximately one per 1000 live births and varies between 0.78 and 12 per 1000 births in general populations. NTDs causation involves multiple genes, nutritional and environmental factors. Research in the next stage should include bigger populations and bigger studies that would be suitable to detect significant links and conclusions with relatively minor risk factors; analysis of multiple candidate genes to detect potential gene-gene interactions; detailed analysis of patient samples stratified by phenotype.


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