Recombinant Pharmaceuticals from Plants: The Plant Endomembrane System as Bioreactor

  Figure 4.
Figure 4.

Human lysozyme is sorted into protein bodies and storage vacuoles in transgenic rice seeds. Electron micrographs of developing seed tissue (i.e., endosperm) of non-transgenic A. and transgenic B. rice seeds. In non-transgenic tissue A. the storage proteins accumulate in ER-derived protein bodies (PB-I) and in protein storage vacuoles (PB-II). In transgenic rice expressing human lysozyme B. the recombinant protein (visualized by immunogold labeling) accumulates in both PB-I-like (arrowheads) and PB-II-like (arrows) structures. Notice the ribosomes decorating the membrane of PB-I, indicating the ER origin. [Reproduced from (60).]

This Article

  1. MI August 2005 vol. 5 no. 4 216-225