Biochemical Mechanisms of Cyclosporine Neurotoxicity

Table 4.

Cyclosporine Concentrations in Rat Brain, Brain Slices, and Mitochondria

Rats were treated with 10 mg/kg/day cyclosporine for 6 days, and rat brain slices were perfused with different cyclosporine concentrations for 4 hours. Data gathered from (1517).
Cyclosporine blood concentrations [ng/ml] Cyclosporine in the brain [ng/g] Cyclosporine in brain mitochondira [ng/g]
409±133 222±35 68.3±14.8
Cyclosporine in the perfusion medium [ng/ml] Cyclosporine in brain slices [ng/g] Cyclosporine in brain mitochondria [ng/g]
100 65±13 51±13
500 208±31 81±27
5000 1240±201 589±241

This Article

  1. MI April 2004 vol. 4 no. 2 97-107