Coming of Age:Anti–Cytokine Therapies

  Figure 1.
Figure 1.

Generation of monoclonal antibodies. B-lymphocytes from immunized mice (or transgenic, “humanized” mice) are fused with myeloma cells. Subsequently, the cell producing the antibody of interest is selected. Antibodies are characterized by two Fab domains which contain the complimentarity-determining regions (CDR) that provide antigen specificity, and an Fc domain which contains the binding sites necessary for complement fixation and other functions.

This Article

  1. MI February 2002 vol. 2 no. 1 36-46