CHK1 Inhibitors in Combination Chemotherapy

Figure 3
Figure 3 Inhibition of CHK1 and activation of ATM and CDK1

Activated ATM and CDK1 can promote cell killing which is suppressed by a compensatory survival signal through ERK1/2. Inhibition of this ERK1/2 survival signal shifts the balance of signaling causing high levels of tumor cell killing.

This Article

  1. MI April 2011 vol. 11 no. 2 133-140