STAT3 SIGNALING: Anticancer Strategies and Challenges

Table 1

STAT3 in the Context of Various Cancers: Validation as an Anticancer Target

Cancers Characterized by Elevated STAT3 Expression or Activity Poor Prognosis Linked to High STAT3 Levels Upstream/Downstream Abnormalities of STAT3 Signaling Xenograft Models Responsive to Inhibition of STAT3
Leukemia
Lymphomas
Multiple myeloma
Breast cancer
Prostate carcinoma
Lung cancer (non-small-cell)
Renal cell carcinoma lung cancer
Hepatocellular carcinoma
Cholangiocarcinoma
Ovarian carcinoma
Pancreatic adenocarcinoma
Melanoma
Head and neck squamous cell carcinoma 		Renal cell carcinoma
Colorectal cancer
Ovarian carcinoma
Gastric carcinoma
Intestinal-type gastric adenocarcinoma
Cervical squamous-cell carcinoma
Osteosarcoma
Epithelial ovarian carcinoma 		Elevated EGFR expression
Constitutively activated EGFR-RTK
Overexpression of SFKs
Hyperactivated JAKs
Elevated TGFα/IL-6 		Head and neck squamous cell carcinoma
Gliobastoma
Myeloproliferative neoplasms
Renal cell carcinoma
Breast cancer
Lung adenocarcinoma
Acute lymphoblastic leukemia

This Article

  1. MI February 2011 vol. 11 no. 1 18-26
  1. AbstractFree
  2. Full Text
  3. Full Text (PDF)

Current Issue

  1. April 2011, 11 (2)
  1. Current Issue
  1. Alert me to new issues of MI
Society Logo HighWire Press Logo CLOCKSS logo