Mechanisms of Pathogenesis in Drug Hepatotoxicity Putting the Stress on Mitochondria

  1. Dean P. Jones1,
  2. John J. Lemasters2,
  3. Derick Han3,
  4. Urs A. Boelsterli4 and
  5. Neil Kaplowitz3
  1. 1 Dept of Medicine, Emory University, 4131 Rollins Research Center, Atlanta, GA 30322
  2. 2 Dept of Pharmaceutical Sciences, 280 Calhoun St, MUSC, Charleston, SC 29425
  3. 3 Keck School of Medicine, 2011 Zonal Ave, Los Angeles, CA 90033
  4. 4 University of Connecticut School of Pharmacy, 69 N Eagleville Rd, Storrs, CT 06269


Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.

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