• Institution: LOCKSS
LOCKSS

Pharmacogenetics of Anticoagulants

  1. Anders Rane anders.rane{at}ki.se1,2
  2. Jonatan D. Lindh jonatan.lindh{at}ki.se1
  1. 1Division of Clinical Pharmacology, Karolinska Institutet, 17177 Stockholm, Sweden
  2. 2Department of Clinical Pharmacology, C1-68, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden

Abstract

Warfarin, acenocoumarol, and phenprocoumon are among the major anticoagulant drugs worldwide. Because of their low therapeutic index and serious adverse reactions (ADRs), their wide use, and their varying kinetics and pharmacogenetic dependence, it is of great importance to explore further possibilities to forecast the dose beyond conventional INR measurements. Here, we describe particulars of the relative pharmacogenetic influence on the kinetics of these agents, the population distribution of genetics risk groups, and novel data on clinical features with influence on dose requirement and ADR risk. The usefulness of genetic information prior to and soon after start of therapy is also discussed. The current renewed focus on these issues is caused not only because of new genetic knowledge and genotyping facilities but also because of the high rate of serious ADRs. Application of these measures in the care of patients with anticoagulant therapy is important awaiting new therapeutic principles to be introduced, which may take long time still.

  • Received June 10, 2010.
  • Accepted August 17, 2010.
|

This Article

  1. doi: 10.4061/2010/754919 Hum Genomics Proteomics 754919

Share