Human Papillomavirus Infection-Reply
Gary R. Newkirk, MD
University of Washington Spokane
Arch Fam Med. 1994;3(10):856.
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I appreciate the opportunity to respond to Reed and Zazove's comments regarding my Editorial "Human Papillomavirus: To Screen or Not to Screen."1 From their comments, I am a bit at a loss to understand in which areas we have substantial differing opinion. It appears that we concur on a number of my expressed concerns and observations regarding the relevance of PCR screening or detection of women at high risk of cervical lesions. It appears to me that from their response we agree on the following: (1) Papanicolaou screening for cervical cancer has problems; (2) cervical cancer does not develop in the vast majority of women with cervical HPV infection; (3) that even though certain subtypes of HPV correlate with progression of HPV infection in some women and that these subtypes can be detected with PCR technology, cervical cancer does not develop in most women with these subtypes; (4) further
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